Today, when I opened up Outlook, connected to a local Exchange server, I got an error message that it couldn't open the default folder, that connection was not available. At first I thought it was a server issue, but my phone showed emails OK (Activesync), and OWA was working fine too. I also tried on another computer, and I was able to set up my mail account on it with Outlook just fine.

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So I tried a few things, checking the server settings etc. On Outlook, but nothing helped. I uninstalled it, and reinstalled it. Now when I start it up, I get 'The connection to Microsoft Exchange is unavailable. Outlook must be online or connected to complete this action.'

The network is fine, my internet connection is OK, and I'm on the same subnet as the Exchange server. There are now firewalls installed at either end. I can ping the Exchange server, and I can even browse its resources. In IE settings the proxy server setting is unchecked. So why can't Outlook connect to Exchange? Maybe I'll try manually deleting the Outlook profile, unless there are some other suggestions.

I upgraded to Windows 10 on Wednesday. No problems with the install, I was able to use all my normal applications fine. Today, I discovered that some emails I'd sent from my work Outlook Exchange account were stuck in outbox. I've had this before in 8.1, but restarting Outlook didn't resolve it as it had before. I have spent hours this evening trying to get it working again with no luck.

I've run scannow as I've seen suggested, which showed no issues. I've removed and reinstalled by exchange account, with my company laptop right next to my Surface Pro 3 to make sure I'm exactly duplicating the settings. Both computers are right next to each other, each connected to the same network, and the Windows 7 laptop is working perfectly while the Windows 10 Surface will not connect.

Hi Guys, I'm having the same issues as this except that I am trying to connect a brand new laptop with a brand new instance of Office 2013. The main problem for me is that i have tried all of the above suggestions and solution but they do not work. I can connect to my Mail exchange with mobiles and via my work domain. I am trying to connect the laptop to the exchange server so they can use it at home away from the domain (they will never log the laptops onto the domain). I would appreciate a nudge in the right direction to fix this.